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Siriraj Center for Regenerative Medicine
Research interest
Siriraj Center for Regenerative Medicine (SiCRM) has a mission to develop cell-based therapy for regenerative medicine and study disease pathogenesis using patient-specific stem cells. Our platform technology is based on induced pluripotent stem cell (iPSCs) technology and cellular differentiation into multiple cell types. We also use genome engineering strategy to correct genetic mutations or enhance the functions of the cells to develop new therapeutic approaches to treat degenerative diseases, genetic diseases, infectious diseases as well as cancers. Furthermore, we also provide training for postgraduate students with fundamental knowledge and expertise in advanced research to translate their findings into clinics. Our research interests include.
- Generation of patient-specific induced pluripotent stem cells (iPSCs) for disease modeling and cell-based therapy of beta-thalassemia, diabetes mellitus (MODY), androgenetic alopecia, spinocerebellar ataxia type 3 and distal renal tubular acidosis.
- Generation of hypoimmunogenic iPSCs for universal transplantation.
- Generation of engineered iPSC-derived immune cells for adoptive cell therapy.
- Generation of iPSC-derived liver organoids for studying host-pathogen interactions in infectious diseases such as malaria and amoebiasis.
- Development of anti-HIV gene therapy using engineered iPSC-derived hematopoietic stem/progenitor cells for treating HIV-1 infection.
Publication
Member list
Contact
Address :
Siriraj Center for Regenerative Medicine
Siriraj Medical Research Center Building (SiMR), Floor 6
Faculty of Medicine Siriraj Hospital, Mahidol University
2 Wanglang Road, Siriraj, Bangkok Noi, Bangkok, THAILAND, 10700
Tel. :
02-4192958
E-mail :
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