Siriraj Metabolomics and Phenomics Center (SiMPC)

www.si.mahidol.ac.th/th/research-academics/research/simpc/



Research interest

The Faculty of Medicine Siriraj Hospital has already conducted genomics and proteomics clinical research. With this in mind, we now are integrating activities in the new Siriraj Metabolomics and Phenomics Center (SiMPC), which will provide education, training, research, and service in the fields of metabolomics and phenomics. The science of metabolomics and phenomics is growing rapidly. Our knowledge base comprises genome, proteome, metabolome, analyses tools, and bioinformatics approaches to analyze this big data system in biology/medicine. These advances allow us to understand health and life, that is, personalized medicine, and to conduct precision medicine1 using big data analysis. The scope of diseases and research topics will focus initially on diabetes mellitus, cancer, cardiovascular disease, dengue hemorrhagic fever, transplantation and Thai traditional medicine.
Metabolomics is the study of metabolism, specifically the science of identifying and quantifying the biochemical by-products of metabolism. By quantifying the changes taking places inside cells or body fluids at specific times and under specific environmental conditions, metabolomics offer new insights into cellular biology and a new path of research into complex diseases and their treatments2. This study is performed using advanced technologies, such as mass spectrometry, combined with sophisticated statistical methods for data interpretation. Metabolomics is connected to all other “omics” but is more time sensitive.
Phenomics uses high throughput (HT) technologies to identify and/or characterize direct products of gene-environment interactions on an individual basis, or for a group operating throughout development and life3. Phenomics uses an integrated set of global measureable physical and clinical features coupled to chemical, metabolic, and physiological properties that define biological sub-classes. Phenomics extends research to “multi-omics” study coupled with the study of systems biology/medicine leading to personalized data.
Using an integrated big data network at Siriraj Hospital will lead to the development of precision medicine and facilitate the translation of scientific knowledge into clinical practice for high impact diseases.



Publication

จำนวนผลงานตีพิมพ์ทั้งหมด : 222 รายการ แสดง 5 รายการ

Theerathananon W, Watanapa WB, Wataganara T, Pratumvinit B, Rahman S.
Preeclamptic serum and soluble fms-like tyrosine kinase-1 suppress endothelial inward rectifier potassium currents.
Journal Name :  Placenta.  2024.  146  101-109.
Department : Physiology/Obstetrics and Gynecology/Clinical Pathology
Source : Pubmed

Vannabhum M, Mahajaroensiri S, Pattanapholkornsakul S, Tantiwongsekunakorn A, Thippayacharoentam T, Tripatara P, Akarasereenont P. .
Metabolomics of Personalized Body Elements in Thai Traditional Medicine Response to Herbal Medicine for Body Elements Balancing in Healthy Volunteers .
Journal Name :  Evid Based Complement Alternat Med.  2023. 
Department : Pharmacology/Center of Applied Thai Traditional Medicine/Siriraj Metabolomics and Phenomics Center
Source : Pubmed

Winayanuwattikun W.; Varothai S.; Tuchinda P.; Kulthanan K.; Prasertworonun N.; Dasri P.; Wanichthanarak K.; Akarasereenont P. .
A double-blinded, randomized, split-side, vehicle-controlled study of the efficacy of cleanser containing Acanthus ebracteatus Vahl., Suregada multiflora, and Acacia concinna in patients with atopic dermatitis: A pilot study .
Journal Name :  Asian Pacific Journal of Allergy and Immunology.  2023.  41  (4): 304-310.
Department : Dermatology/Pharmacology/Center of Applied Thai Traditional Medicine
Source : Scopus

Watcharasirikul N., Vannabhum M., Yamthed R., Srikhlo T., Akarasereenont P., Harnphadungkit K. .
Comparative Effectiveness of Court-Type Thai Traditional Massage and Ultrasound Therapy in Patients with Neck Pain: A Randomized Controlled Trial .
Journal Name :  Siriraj Medical Journal.  2023.  75  (1): 29-37.
Department : Center of Applied Thai Traditional Medicine/Rehabilitation Medicine
Source : Scopus

Shunkao S., Theerakulpisut P., Wanichthanarak K., Pongdontri P., Thitisaksakul M. .
Integrative physiological and metabolomics study reveals adaptive strategies of wheat seedlings to salt and heat stress combination .
Journal Name :  Plant Growth Regulation.  2023. 
Department : Siriraj Metabolomics and Phenomics Center
Source : Scopus

All Publication     



Contact

Address :  
Siriraj Metabolomic And Phenomic Center
Sri Savarindira Building, Floor 10
Faculty of Medicine Siriraj Hospital, Mahidol University
2 Wanglang Road, Siriraj, Bangkok Noi, Bangkok, THAILAND, 10700


Tel. :  
02-419-5505


E-mail :  
simpc.mu@gmail.com

© Research Division - 2022