Siriraj Medical Research Network (SiMRN)


Viral and host factors for HIV curd

Research mission /Objective

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Investigator / Research network team

- Assoc. Prof. WinaiRatanasuwan

The scope of the research/expertise

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International Research Collaboration

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Participants

No. Name Department CV
1 Assoc. Prof. Winai Ratanasuwan Preventive and Social Medicine  
2 Dr. Boonrat Tassaneetrithep Preventive and Social Medicine  
3 Dr. Bhoom Suktitipat Biochemistry  
4 Dr. Navin Horthongkham Microbiology  
5 Dr. Adhiratha Boonyasiri Research and Development  
6 Assoc. Prof. Wannee Kantakamalakul Microbiology  
7 Asst. Prof. Somruedee Chatsiricharoenkul Pharmacology  
8 Dr. Phornnop Naiyanetr Immunology  
9 Dr. Pornpoj Pramyothin Medicine  
10 Dr. Rujipas Sirijatuphat Medicine  
11 Dr. Nuttasith Larpparisuth Medicine  

Research projects

No. Project Sponsor Funding status
1 Mitochondrial DNA analysis of the Myanmar immigrants entering Thailand through the Thai Immigration Office at Kanchanaburi province: towards the establishment of the genetic diversity database of the Asean Economic Community Population migrating to Thailand. The Thailand Research Fund-Mahidol University Grant application approved for funding from 2014 to 2016
       

Publications Output (Vancouver style)

  1. Sattayasai J, Chaonapan P, Arkaravichie T, Soi-Ampornkul R, Junnu S, Charoensilp P, et al. Protective effects of mangosteen extract on H2O2-induced cytotoxicity in SK-N-SH cells and scopolamine-induced memory impairment in mice. PloS one. 2013;8(12):e85053. PubMed PMID: 24386444. Pubmed Central PMCID: 3874002.

  2. Kim Y, Suktitipat B, Yanek LR, Faraday N, Wilson AF, Becker DM, et al. Targeted deep resequencing identifies coding variants in the PEAR1 gene that play a role in platelet aggregation. PloS one. 2013;8(5):e64179. PubMed PMID: 23704978. Pubmed Central PMCID: 3660448.

  3. Suktitipat B, Mathias RA, Vaidya D, Yanek LR, Young JH, Becker LC, et al. The robustness of generalized estimating equations for association tests in extended family data. Human heredity. 2012;74(1):17-26. PubMed PMID: 23038411. Pubmed Central PMCID: 3736986.

  4. N'Diaye A, Chen GK, Palmer CD, Ge B, Tayo B, Mathias RA, et al. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. PLoS genetics. 2011 Oct;7(10):e1002298. PubMed PMID: 21998595. Pubmed Central PMCID: 3188544.

  5. Faraday N, Yanek LR, Yang XP, Mathias R, Herrera-Galeano JE, Suktitipat B, et al. Identification of a specific intronic PEAR1 gene variant associated with greater platelet aggregability and protein expression. Blood. 2011 Sep 22;118(12):3367-75. PubMed PMID: 21791418. Pubmed Central PMCID: 3179402.

  6. Mathias RA, Sergeant S, Ruczinski I, Torgerson DG, Hugenschmidt CE, Kubala M, et al. The impact of FADS genetic variants on omega6 polyunsaturated fatty acid metabolism in African Americans. BMC genetics. 2011;12:50. PubMed PMID: 21599946. Pubmed Central PMCID: 3118962.

  7. Kaewsutthi S, Phasukkijwatana N, Joyjinda Y, Chuenkongkaew W, Kunhapan B, Tun AW, et al. Mitochondrial haplogroup background may influence Southeast Asian G11778A Leber hereditary optic neuropathy. Investigative ophthalmology & visual science. 2011 Jun;52(7):4742-8. PubMed PMID: 21398275.

  8. Kral BG, Mathias RA, Suktitipat B, Ruczinski I, Vaidya D, Yanek LR, et al. A common variant in the CDKN2B gene on chromosome 9p21 protects against coronary artery disease in Americans of African ancestry. Journal of human genetics. 2011 Mar;56(3):224-9. PubMed PMID: 21270820. Pubmed Central PMCID: 3079521.

  9. Assimes TL, Holm H, Kathiresan S, Reilly MP, Thorleifsson G, Voight BF, et al. Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. Journal of the American College of Cardiology. 2010 Nov 2;56(19):1552-63. PubMed PMID: 20933357. Pubmed Central PMCID: 3084526.

  10. Sun H, SwaimA, Herrera JE, Becker D, Becker L, Srivastava K, et al. Platelet kainate receptor signaling promotes thrombosis by stimulating cyclooxygenase activation. Circulation research. 2009 Sep 11;105(6):595-603. PubMed PMID: 19679838. Pubmed Central PMCID: 2771168.

  11. Klein AP, Suktitipat B, Duggal P, Lee KE, Klein R, Bailey-Wilson JE, et al. Heritability analysis of spherical equivalent, axial length, corneal curvature, and anterior chamber depth in the Beaver Dam Eye Study. Archives of ophthalmology. 2009 May;127(5):649-55. PubMed PMID: 19433716. Pubmed Central PMCID: 2739587.

  12. Lertrit P, Poolsuwan S, Thosarat R, Sanpachudayan T, Boonyarit H, Chinpaisal C, et al. Genetic history of Southeast Asian populations as revealed by ancient and modern human mitochondrial DNA analysis. American journal of physical anthropology. 2008 Dec;137(4):425-40. PubMed PMID: 18615504.

  13. Chen GK, Zheng T, Witte JS, Goode EL, Gao L, Hu P, et al. Genome-wide association analyses of expression phenotypes. Genetic epidemiology. 2007;31Suppl 1:S7-S11. PubMed PMID: 18046762.

  14. Tharaphan P, Chuenkongkaew WL, Luangtrakool K, Sanpachudayan T, Suktitipat B, Suphavilai R, et al. Mitochondrial DNA haplogroup distribution in pedigrees of Southeast Asian G11778A Leber hereditary optic neuropathy. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. 2006 Dec;26(4):264-7. PubMed PMID: 17204919.

  15. Phasukkijwatana N, Chuenkongkaew WL, Suphavilai R, Suktitipat B, Pingsuthiwong S, Ruangvaravate N, et al. The unique characteristics of Thai Leber hereditary optic neuropathy: analysis of 30 G11778A pedigrees. Journal of human genetics. 2006;51(4):298-304. PubMed PMID: 16477364.

  16. Chuenkongkaew WL, Suphavilai R, Vaeusorn L, Phasukkijwatana N, Lertrit P, Suktitipat B. Proportion of 11778 mutant mitochondrial DNA and clinical expression in a thai population with leber hereditary optic neuropathy. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. 2005 Sep;25(3):173-5. PubMed PMID: 16148621.

  17. Horthongkham N, Athipanyasilp N, Sirijatuphat R, Assanasen S, Sutthent R. Prevalence and Molecular Characterization of Human Metapneumovirus in Influenza A Negative Sample in Thailand.. J Clin Lab Anal. 2014 Mar 20. doi: 10.1002/jcla.21700

  18. Ammaranond P, Sanguansittianant S, Raju PA, Cunningham P, Horthongkham N. Development of a cost-effective assay for genotyping of HIV-1 non-B subtype for drug resistance. J Virol Methods. 2014 Apr;199:102-7. doi: 10.1016/j.jviromet.2014.01.007. Epub 2014 Jan 22.

  19. Horthongkham N, Athipanyasilp N, Siritantikorn S, Kantakamalakul W, Srisurapanon S, Sutthent R. Structure and function of HIV-1 CRF01_AE envelope proteins from blood and genital fluid isolates. Southeast Asian Trop med Pub Health 2009;40:480-93.

  20. Niyasom C, Horthongkham N, Sreepian A, Kantakamalakul W, Louisirirotchanakul S, Chuenchitra T, Sutthent R. HIV-1 subtype B tat gene activities and disease progression in HIV-1 CRF01_AE infection. Southeast Asian Trop med Pub Health 2009;40:748-58.

  21. Sumonwiriya M, Horthongkham N, Pattanapanyasat K, Ampol S, Sutthent R, Kantakamalakul W. Stable expression of EBV-gp350 on the surface of NC37 cells confers natural killer (NK)-cell susceptibility or resistance, depending on the assay used to assess NK-mediated function. J Virol Methods. 2009 Oct;161(1):154-60. Epub 2009 Jun 17.

  22. Horthongkham N, Srihtrakul T, Athipanyasilp N, Siritantikorn S, Kantakamalakul W, Poovorawan Y, Sutthent R. Specific antibody response of mice after immunization with COS-7 cell derived avian influenza virus (H5N1) recombinant proteins. J Immune Based Ther Vaccines. 2007 Oct 3;5:10

  23. Sreepian A, Horthonghkham N, Srisurapanon S, Tunsupasawasdikul S, Kaoriangudom S, Khusmith S, Sutthent R. Conserved neutralizing epitopes of HIV-1 CRF01_AE against primary isolates in long-term nonprogressors. AIDS Res Hum Retroviruses 2004;20(5):31-42.

  24. Sutthent R, Kanoksinsombat C, Horthongkham N, Louisirirotchanakul S, Auewarakul P, and Kantakamalakul W. Recombinant envelope protein of HIV-1 subtype E as antigen in HIV-1 antibody detection enzyme immunoassay. Southeast Asian Trop med Pub Health 2002;33:288-96.

  25. Puthavathana P, Horthongkham N, Roongpisuthipong A, Maythangkul P, Kanyok R, Boonsirikhamchai P, Chaiyakul P. Comparison between virus isolation method, Papanicolaou stain, immunoperoxidase stain and polymerase chain reaction in the diagnosis of genital herpes. Asian Pac J Allergy Immunol. 1998 Dec;16(4):177-83.

  26. Puthavathana P, Kanyok R, Horthongkham N, Roongpisuthipong A. Prevalence of herpes simplex virus infection in patients suspected of genital herpes; and virus typing by type specific fluorescent monoclonal antibodies. J Med Assoc Thai. 1998 Apr;81(4):260-4.

Output/Rewards

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Faculty of Medicine Siriraj Hospital, Mahidol University
His Majesty the King’s 80th Birthday Anniversary 5th December 2007 Building.
2 Wanglang Road Bangkoknoi, Bangkok 10700, Thailand